Researchers from the University of Alberta have come up with a way to use a cyclotron to produce the medical isotopes needed to diagnose certain health conditions, like cancer and heart disease.
The cyclotron is a particle accelerator that can produce technetium-99m, a radioactive tracer that can be detected in the body by medical equipment.
Technetium is usually supplied through nuclear reactors that produce molybdenum-99, a radioactive isotope that decays to produce technetium.
The U of A’s cyclotron can produce the technetium directly.
This allows scientists to generate a steady supply, potentially addressing the needs of the entire province, said Sandy McEwan, a professor of oncology at the university.
“We can make the daily production responsive to the daily need of the system, and we can also bypass the multiple steps that are required from the reactor,” said McEwan.
Since the machine is powered electrically, it doesn’t produce any nuclear waste.
“It’s much cleaner, much safer. That’s why you can have a cyclotron facility in the middle of the city with no repercussions,” said John Wilson, who heads the university’s cyclotron facility.
Isotopes for the future
The cyclotron can also produce other types of medical isotopes, or radionuclides, including the ones used in positron emission tomography (PET) imaging.
Currently, 80 per cent of imaging is done with technetium, but researchers believe that PET will replace it over the next 10 years as the technology of choice in diagnostics.
“The newer radionuclides that are used, the so-called PET imaging agents, give a much more high-resolution picture,” said Wilson. “We’re slowly moving toward more PET isotopes.”
As the medical industry transitions to PET imaging, the U of A’s cyclotron will be able to transition with it.
“With our technology, we can easily switch to the new ones,” said Jan Andersson, a radiochemist with the U of A.
Most of the world’s medical isotopes are produced by five or six nuclear reactors, that are around 40 years old, explained Andersson.
The reactors occasionally go down, and are costly and time–consuming to repair.
“It made the supply chain more fragile,” said Andersson. “So when one of the other reactors needs service or maintenance, there can be interruptions in the supply.”
The federal government funded the university’s cyclotron research to address these shortages.
After more than three years of work, the scientists have shown that the cyclotrons can add to the supply chain when reactors are out of service.
Yet the future of the University of Alberta’s cyclotron is up in the air.
“It’s going to be up to the federal and provincial governments to determine the way they want to go regarding this,” said Andersson.
Marketing the technology
While the technology used in the U of A’s cyclotron is proven, it hasn’t been commercialized.
The technetium is a tag, it needs to be attached to a drug, a specific molecule, in order to function as a diagnostic tool.
“There’s a vast array of potential, we just provide the appropriate tag so it can be followed for imaging,” said Wilson.
The researchers must obtain regulatory approval from Health Canada to be able to market the product, and for clinical use.
More work also needs to be done to establish the financial viability of the cyclotron.
Many factors, like the cost of building the facilities and decommissioning a nuclear reactor, have to be considered, said McEwan.
“Our preliminary indications are good,” he said. “Now that we’ve done these bulk productions, we have to validate the cost.”
The researchers will also work on automating the process to make the raw materials that go into the cyclotron to produce the technetium.
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Sherwood Park is a large hamlet in Alberta, Canada within Strathcona County that is recognized as an urban service area. It is located adjacent to the City of Edmonton’s eastern boundary, generally south of Highway 16 (Yellowhead Trail), west of Highway 21 and north of Highway 630 (Wye Road). Other portions of Sherwood Park extend beyond Yellowhead Trail and Wye Road, while Anthony Henday Drive (Highway 216) separates Refinery Row to the west from the balance of the hamlet to the east.
Sherwood Park was established in 1955 on farmland of the Smeltzer family, east of Edmonton. With a population of 70,618 in 2016, Sherwood Park has enough people to be Alberta’s seventh largest city, but technically retains the status of a hamlet. The Government of Alberta recognizes the Sherwood Park Urban Service Area as equivalent to a city.
Sherwood Park, originally named Campbelltown, was founded by John Hook Campbell and John Mitchell in 1953 when the Municipal District of Strathcona No. 83 approved their proposed development of a bedroom community east of Edmonton. The first homes within the community were marketed to the public in 1955. Canada Post intervened on the name of Campbelltown due to the existence of several other communities in Canada within the same name, so the community’s name was changed to Sherwood Park in 1956.
The Sherwood Park Urban Service Area is located in the Edmonton Capital Region along the western edge of central Strathcona County adjacent to the City of Edmonton. The majority of the community is bound by Highway 16 (Yellowhead Highway) to the north, Highway 21 to the east, Highway 630 (Wye Road) to the south, and Anthony Henday Drive (Highway 216) to the west. The Refinery Row portion of Sherwood Park is located across Anthony Henday Drive to the west, between Sherwood Park Freeway and Highway 16. Numerous developments fronting the south side of Wye Road, including Wye Gardens, Wye Crossing, Salisbury Village and the Estates of Sherwood Park, are also within the community. Lands north of Highway 16 and south of Township Road 534/Oldman Creek between Range Road 232 (Sherwood Drive) to the west and Highway 21 to the east are also within the Sherwood Park urban service area.